Resistance to a deadly disease in Tilapia fish is mainly caused by genetic differences between families of the same fish. Image Selective breeding to produce virus-resistant fish is likely to be effective. The deadly Tilapia Lake Virus (TiLV) is very heritable, scientists found. This means that selective breeding to produce more resistant tilapia strains is likely to be effective. The findings could help protect stocks of Tilapia fish, which is the second most farmed fish in the world, an important food source in Africa, Asia and South America, and worth nearly $10 billion to the global economy. Heritable virus Researchers from the Roslin Institute and WorldFish analysed the genes of 1,821 Genetically Improved Farmed Tilapia (GIFT), which were tagged and placed in a pond that had an outbreak of TiLV. The fish were members of 124 families and the team discovered that there was a large variation in family survival. Some family groups had no deaths, whereas others found to have a 100 per cent death rate. Fish growth Future breeding programmes for GIFT that produce fish resistant to the virus will not adversely affect the growth of the fish and will benefit farmers’ yields, the researchers found. The GIFT strain has been selectively bred to be fast growing and adaptable to a wide range of environments. The strain is produced in at least 14 countries, helping to reduce poverty and hunger. Global disease Since its detection in 2014, TiLV has ravaged Tilapia populations in 16 countries across three continents. There are currently no treatments or vaccines for TiLV, which causes behavioural changes in tilapia, discoloration, skin hemorrhages, loss of scales, eyeball protrusion, abdominal swelling, with up to 90 per cent of fish dying once infected. Tilapia Lake Virus poses a real problem to fish famers worldwide, impacting on the livelihoods and food security of millions of people. This research is the result of a long term collaboration between Roslin and WorldFish, and is the first step to breeding tilapia strains with improved resistance to the virus. Professor Ross HoustonLead author and Personal Chair of Aquaculture Genetics, the Roslin Institute This study, published in the journal Aquaculture, was funded with UK aid from the UK government and was undertaken in the framework of the CGIAR Research Program on Fish Agri-Food Systems. About the Royal Dick School of Veterinary Studies The Royal (Dick) School of Veterinary Studies is a one-of-a-kind centre of excellence in clinical activity, teaching and research. Our purpose-built campus, set against the backdrop of the beautiful Pentland Hills Regional Park, is home to more than eight hundred staff and almost fourteen hundred students, all of whom contribute to our exceptional community ethos. The School comprises: The Roslin Institute The Global Academy of Agriculture and Food Security The Roslin Innovation Centre The Hospital for Small Animals Equine Veterinary Services Farm Animal Services Easter Bush Pathology The Jeanne Marchig International Centre for Animal Welfare Education We represent the largest concentration of animal science related expertise in Europe, impacting local, regional, national and international communities in terms of economic growth, the provision of clinical services and the advancement of scientific knowledge. Publication date 26 Feb, 2020
