VACCINE

This project uses a novel surgical method to access cells draining from vaccine sites. The aim is to define the responses to vaccines that induce protective immunity compared to vaccines which do not protect. Identifying specific cells or pathways that correlate to immunity can then be further exploited in vaccine or adjuvant design.

The work is funded by Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (2017-2021).

Team members: Heather Mathie, Lindsey Waddell and Sara Marzo

Team partners: Tim Connelley, Anirudh Patel, Barbara Shih and Ivan Morrison

Key references:

Hope, J. C., Howard, C. J., Prentice, H., & Charleston, B. (2006). Isolation and purification of afferent lymph dendritic cells that drain the skin of cattle. Nat. Prot. 1(2), 982–987. https://doi.org/10.1038/nprot.2006.125

Hope, J. C., Guzman, E., Cubillos-Zapata, C., Stephens, S. A., Gilbert, S. C., Prentice, H., Sopp, P., Howard, C. J., & Charleston, B. (2012). Migratory sub-populations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin. Vaccine, 30(13), 2357–2367. https://doi.org/10.1016/j.vaccine.2012.01.036