White Leghorn inbred lines have been extensively used for many years to investigate the genetic basis of disease resistance and susceptibility (1-3). MHC haplotypes and known resistance and susceptibility are detailed below*. *The MHC haplotypes, differential resistance, and susceptibilities of the lines to pathogens itemised below have not been validated in recent years. These lines are available from the SPF unit Availability: Currently, we have a limited egg supply between March-August. Eggs are not available from September to February. Please note, that these dates can vary slightly from year to year. Eggs and chicks can be provided in larger numbers and outwith their usual availability with advanced notice of about 6 months. Contact the NARF directly with requests (narf@roslin.ed.ac.uk). Line 61 Origin ADOL East Lansing, 1939. Imported 1972. MHC: B2. Susceptible to ALV, subgroups A, B, C, & D. Resistant to MDV and ALV tumour development. Histocompatible with Line 72 skin grafting, cell exchange. Line 72 Origin ADOL East Lansing, 1939. Imported 1972. MHC: B2. Susceptible to ALV, subgroups A, B, D, & E, and MDV. Resistant to ALV tumour development. Histocompatible with Line 61 skin grafting, cell exchange. Line 15I Origin ADOL East Lansing, 1939. Imported 1962. MHC: B15. Susceptible to ALV subgroups A, C; segregating for B, D, E. Moderately susceptible to MDV. Line C b4 Origin Reaseheath Laboratory, Cambridge UK. Imported 1969. MHC: B4/B4. Susceptible to ALV, subgroups B, C, & D. Resistant to MDV. Line C b12 Origin Reaseheath Laboratory. Relocated to Compton 1969. MHC: B12/B12. Susceptible to ALV, subgroups B, C, & D. Resistant to MDV. Line N Origin Cornell University, USA. Imported 1982. MHC: B21. Resistant to MDV tumour development. Line 0 Origin ADOL East Lansing. Imported 1985. MHC: B21. Susceptible to ALV, subgroups A, B, C, & D. Free of endogenous ALV genes (ev loci) by DNA hybridization. Line P2a Origin Cornell University, USA. Imported 1996. MHC: B19. Susceptible to MDV. Line W Origin Wellcome Research Laboratory. Relocated to Compton 1982. MHC: B14. Expand all Collapse all Publications Bacon, L. D., H. D. Hunt, and H. H. Cheng. 2000. A review of the development of chicken lines to resolve genes determining resistance to diseases. Poult. Sci. 79:1082-1093. Stone, H.A. 1975. Use of highly inbred chickens in research. USDA-ARS Technical Bulletin No. 1514, Washington, DC. Waters, N. F. 1945. Breeding for Resistance and Susceptibility to Avian Lymphomatosis. Poult. Sci. 24:259-269. This article was published on 2024-09-02
