Selected articles Dual pathogenicity island transfer by piggybacking lateral transduction Chee MSJ, Serrano E, Chiang YN, Harling-Lee J, Man R, Bacigalupe R, Fitzgerald JR, Penadés JR, Chen J. Dual pathogenicity island transfer by piggybacking lateral transduction. Cell. 2023 August; 186(16):414-3426. e16. doi: https://doi.org/10.1016/j.cell.2023.07.001 Rapid metagenomic sequencing for diagnosis and antimicrobial sensitivity prediction of canine bacterial infections Ring N, Low AS, Wee B, Paterson GK, Nuttall T, Gally D, Mellanby R, Fitzgerald JR. Rapid metagenomic sequencing for diagnosis and antimicrobial sensitivity prediction of canine bacterial infections. Microb Genom. 2023 July; 9(7):001066. doi: https://doi.org/10.1099/mgen.0.001066 Nanoscaled Discovery of a Shunt Rifamycin from Salinispora arenicola Using a Three-Color GFP-Tagged Staphylococcus aureus Macrophage Infection Assay Pham NT, Alves J, Sargison FA, Cullum R, Wildenhain J, Fenical W, Butler MS, Mead DA, Duggan BM, Fitzgerald JR, La Clair JJ, Auer M. ACS Infect. Dis. 2023 July; 9(8):1499-1507. doi: https://doi-org.ezproxy.is.ed.ac.uk/10.1021/acsinfecdis.3c00049 Methicillin-Resistant Staphylococcus aureus in Food Animals: Host-Adaptive Evolution, Epidemiology, and Public Health Threat Larsen AR, Fitzgerald JR, Larsen J. Methicillin-Resistant Staphylococcus aureus in Food Animals: Host-Adaptive Evolution, Epidemiology, and Public Health Threat. Zoonoses: Infections Affecting Humans and Animals. 2023 Mar; 1-16 Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock Yebra G, Harling-Lee JD, Lycett S, Aarestrup FM, Larsen G, Cavaco LM, Seo KS, Abraham S, Norris JM, Schmid T, Ehlers MM, Sordell DO, Buzzola FR, Gebreyes WA, Gonçalves JL, Santos MVD, Zalaria Z, Rall VLM, Keane OM, Niedziela DA, Paterson GK, Holmes MA, Freeman TC, Fitzgerald JR. Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock. PNAS. 2022 Dec 5; 119(50):e2211217119. doi: https://doi.org/10.1073/pnas.2211217119 Staphylococcus Pickering PC, Haag AF, Penades JR, Fitzgerald JR. Staphylococcus. Pathogenesis of Bacterial Infections in Animals. 2022 Aug; Ch25:543-564. doi: https://doi.org/10.1002/9781119754862.ch25 A graph-based approach for the visualisation and analysis of bacterial pangenomes Harling-Lee JD, Gorzynski J, Yebra G, Angus T, Fitzgerald JR, Freeman TC. A graph-based approach for the visualisation and analysis of bacterial pangenomes. BMC Bioinformatics. 2022 Oct 8; 23:416. doi: https://doi.org/10.1186/s12859-022-04898-2 Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives Campos B, Pickering AC, Rocha LS, Aguilar AP, Fabres-Klein MH, de Oliveira Mendes TA, Fitzgerald JR, de Oliveira Barros Ribon. Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives. BMC Veterinary Research. 2022 Mar 24; 18:115. doi: https://doi.org/10.1186/s12917-022-03197-5 Epidemiological analysis of Legionnaires' disease in Scotland: a genomic study Gorzynski J, Wee B, Llano Melissa, Alves J, Cameron R, McMenamin J, Smith A, Lindsay D, Fitzgerald JR. Epidemiological analysis of Legionnaires' disease in Scotland: a genomic study. The Lancet Microbe. 2022 Nov; 3(11):e835-e845. doi: https://doi.org/10.1016/S2666-5247(22)00231-2. RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression McKellar SW, Ivanova I, Arede P, Zapf RL, Mercier N, Chu LC, Mediati DG, Pickering AC, Briaud P, Foster RG, Kudla G, Fitzgerald JR, Caldelari I, Carroll RK, Tree JJ, Granneman S. RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression. Nat Commun. 2022 June 22; 13:3560. doi: https://doi.org/10.1038/s41467-022-31173-y Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing. Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR. Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing. Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. PMID: 34887398. Evolutionary and functional analysis of coagulase positivity among the staphylococci. Pickering AC, Yebra G, Gong X, Goncheva MI, Wee BA, MacFadyen AC, Muehlbauer LF, Alves J, Cartwright RA, Paterson GK, Fitzgerald JR. Evolutionary and Functional Analysis of Coagulase Positivity among the Staphylococci. mSphere. 2021 Aug 25;6(4):e0038121. doi: 10.1128/mSphere.00381-21. Epub 2021 Aug 4. PMID: 34346700; PMCID: PMC8386474. Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. Liu Y, Ling L, Wong SH, Wang MH, Fitzgerald JR, Zou X, Fang S, Liu X, Wang X, Hu W, Chan H, Wang Y, Huang D, Li Q, Wong WT, Choi G, Zou H, Hui DS, Yu J, Tse G, Gin T, Wu WK, Chan MT, Zhang L. Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine. 2021 Jun 10;37:100955. doi: 10.1016/j.eclinm.2021.100955. PMID: 34386745; PMCID: PMC8343259. Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen. Yebra G, Haag AF, Neamah MM, Wee BA, Richardson EJ, Horcajo P, Granneman S, Tormo-Más MÁ, de la Fuente R, Fitzgerald JR, Penadés JR. Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen. PLoS Pathog. 2021 May 20;17(5):e1009606. doi: 10.1371/journal.ppat.1009606. PMID: 34015034; PMCID: PMC8171923. Staphylococcus aureus secreted lipases do not inhibit innate immune killing mechanisms. F Sargison, J Alves, A Pickering, JR Fitzgerald. Wellcome Open Research 5 (286), 286. Advances in transposon mutagenesis of staphylococcus aureus: insights into pathogenesis and antimicrobial resistance. Sargison FA, Fitzgerald JR. Trends Microbiol. 2020 Dec 2:S0966-842X(20)30294-8. doi: 10.1016/j.tim.2020.11.003. The role of gram-positive surface proteins in bacterial niche- and host-specialization. Pickering AC, Fitzgerald JR. Front Microbiol. 2020 Oct 29;11:594737. doi: 10.3389/fmicb.2020.594737. A case report: insights into reducing plastic waste in a microbiology laboratory. Alves J, Sargison F, Stawarz H, Fox W, García Huete S, Hassan A, McTeir B & Pickering A. 2020. Access Microbiology. https://doi.org/10.1099/acmi.0.000173 Population analysis of staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia. Vrieling M, Tuffs SW, Yebra G, van Smoorenburg MY, Alves J, Pickering AC, Park JY, Park N, Heinrichs DE, Benedictus L, Connelley T, Seo KS, McCormick JK, Fitzgerald JR. mBio. 2020 Oct 27;11(5):e02082-20. doi: 10.1128/mBio.02082-20. Acapsular Staphylococcus aureus with a non-functional agr regains capsule expression after passage through the bloodstream in a bacteremia mouse model. Suligoy CM, Díaz RE, Gehrke AK, Ring N, Yebra G, Alves J, Gómez MI, Wendler S, Fitzgerald JR, Tuchscherr L, Löffler B, Sordelli DO, Llana MN, Buzzola FR. Sci Rep. 2020 Aug 24;10(1):14108. doi: 10.1038/s41598-020-70671-1. One Health: a multifaceted concept combining diverse approaches to prevent and control antimicrobial resistance. Guardabassi L, Butaye P, Dockrell DH, Fitzgerald JR, Kuijper EJ; ESCMID Study Group for Veterinary Microbiology (ESGVM). Clin Microbiol Infect. 2020 Dec;26(12):1604-1605. doi: 10.1016/j.cmi.2020.07.012. Staphylococcus aureus lipase 1 enhances influenza A virus replication. Goncheva MI, Conceicao C, Tuffs SW, Lee HM, Quigg-Nicol M, Bennet I, Sargison F, Pickering AC, Hussain S, Gill AC, Dutia BM, Digard P, Fitzgerald JR. mBio. 2020 Jul 7;11(4):e00975-20. doi: 10.1128/mBio.00975-20. Developing novel host-based therapies targeting microbicidal responses in macrophages and neutrophils to combat bacterial antimicrobial resistance. Watson K, Russell CD, Baillie JK, Dhaliwal K, Fitzgerald JR, Mitchell TJ, Simpson AJ, Renshaw SA, Dockrell DH. Front Immunol. 2020 Jun 5;11:786. doi: 10.3389/fimmu.2020.00786. Metagenomic sequencing of clinical samples reveals a single widespread clone of Lawsonia intracellularis responsible for porcine proliferative enteropathy. Bengtsson RJ, Wee BA, Yebra G, Bacigalupe R, Watson E, Guedes RMC, Jacobson M, Stadejek T, Archibald AL, Fitzgerald JR, Ait-Ali T. Microb Genom. 2020 Apr;6(4):e000358. doi: 10.1099/mgen.0.000358. A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Bacigalupe R, Tormo-Mas MA, Pernadés J, Fitzgerald JR. Science Advances. 2019 Nov 27; 10.1126/sciadv.aax0063. Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion. Pickering AC, Vitry P, Prystopiuk V, Garcia B, Höök M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR. PLoS Pathog. 2019 Jun 19;15(6):e1007816. Bovine Staphylococcus aureus superantigens stimulate the entire T cell repertoire of cattle. Wilson GJ, Tuffs SW, Wee BA, Seo KS, Park N, Connelley T, Guinane CM, Morrison WI, Fitzgerald JR. Infect Immun 2018; 86:e00505-18. Gene exchange drives the ecological success of a multi-host bacterial pathogen. Richardson EJ, Bacigalupe R, Harrison EM, Weinert LA, Lycett S, Vrieling M, Robb K, Hoskisson PA, Holden MTG, Feil EJ, Paterson GK, Tong SYC, Shittu A, van Wamel W, Aanensen DM, Parkhill J, Peacock SJ, Corander J, Holmes M, Fitzgerald JR. Nat Ecol Evol 2018; 2:1468. Population genomics of bacterial host adaptation. Sheppard SK, Guttman DS, Fitzgerald JR. Nat Rev Genet 2018; 19: 549. The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function. Tuffs ST, James DBA, Bestebroer J, Richards AC, Goncheva MI, O’Shea M, Wee BA, Seo KS, Schlievert PM, Lengeling A, Van Strijp JA, Torres VJ, Fitzgerald, JR. PLoS Pathogens 2017; 13: e1006461. Population Genomics of Legionella longbeachae and Hidden Complexities of Infection Source Attribution. Bacigalupe R, Lindsay D, Edwards G, Fitzgerald JR. Emerg Infect Dis. 2017; 23: 750. Evolutionary Dynamics of Pandemic Methicillin-Sensitive Staphylococcus aureus ST398 and Its International Spread via Routes of Human Migration. Uhlemann AC, McAdam PR, Sullivan SB, Knox JR, Khiabanian H, Rabadan R, Davies PR, Fitzgerald JR*, Lowy FD*. MBio 2017; 8: e01375-16. [*Joint contributions] Genomics of Natural Populations of Staphylococcus aureus. Fitzgerald JR, Holden MT. Annu Rev Microbiol 2016; 70: 459. Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA. Ward MJ, Goncheva M, Richardson E, McAdam PR, Raftis E, Kearns A, Daum RS, David MZ, Lauderdale TL, Edwards GF, Nimmo GR, Coombs GW, Huijsdens X, Woolhouse ME, Fitzgerald JR. Genome Biol 2016; 17: 160. Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation. Spoor LE, Richardson E, Richards AC, Wilson GJ, Mendonca C, Gupta RK, McAdam PR, Nutbeam-Tuffs S, Black NS, O'Gara JP, Lee CY, Corander J, Fitzgerald JR. Microb Genom 2015; 1: e000036. A single natural nucleotide mutation alters bacterial pathogen host tropism. Viana D, Comos M, McAdam PR, Ward MJ, Selva L, Guinane CM, González-Muñoz BM, Tristan A, Foster SJ, Fitzgerald JR*, Penadés JR*. Nat Genet 2015; 47: 361 [*Joint contributions] Gene flow in environmental Legionella pneumophila leads to genetic and pathogenic heterogeneity within a Legionnaires' disease outbreak. McAdam PR, Vander Broek CW, Lindsay DS, Ward MJ, Hanson MF, Gillies M, Watson M, Stevens JM, Edwards GF, Fitzgerald JR. Genome Biol 2014; 15: 504. Time-Scaled Evolutionary Analysis of the Transmission and Antibiotic Resistance Dynamics of Staphylococcus aureus Clonal Complex 398. Ward MJ, Gibbons CL, McAdam PR, van Bunnik BA, Girvan EK, Edwards GF, Fitzgerald JR, Woolhouse ME. Appl Environ Microbiol 2014; 80: 7275. High-throughput sequencing for the study of bacterial pathogen biology. McAdam PR, Richardson EJ, Fitzgerald JR. Curr Opin Microbiol 2014; 19: 106. Staphylococcus aureus proteins SSL6 and SElX interact with neutrophil receptors as identified using secretome phage display. Fevre C, Bestebroer J, Mebius MM, de Haas CJ, van Strijp JA, Fitzgerald JR, Haas PJ. Cell Microbiol 2014; 16: 1646. Livestock origin for a human pandemic clone of community-associated methicillin-resistant Staphylococcus aureus. Spoor LE, McAdam PR, Weinert LA, Rambaut A, Hasman H, Aarestrup FM, Kearns AM, Larsen AR, Skov RL, Fitzgerald JR. MBio 2013; 4: e00356-13. A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic. Holden MT, Hsu LY, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, de Lencastre H, Skov R, Westh H, Zemlicková H, Coombs G, Kearns AM, Hill RL, Edgeworth J, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramírez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nübel U. Genome Res 2013; 23: 653. Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication. Weinert LA, Welch JJ, Suchard MA, Lemey P, Rambaut A, Fitzgerald JR. Biol Lett 2012; 8: 829. Molecular tracing of the emergence, adaptation, and transmission of hospital-associated methicillin-resistant Staphylococcus aureus. McAdam PR, Templeton KE, Edwards GF, Holden MT, Feil EJ, Aanensen DM, Bargawi HJ, Spratt BG, Bentley SD, Parkhill J, Enright MC, Holmes A, Girvan EK, Godfrey PA, Feldgarden M, Kearns AM, Rambaut A, Robinson DA, Fitzgerald JR. Proc Natl Acad Sci U S A 2012; 109: 9107. Livestock-associated Staphylococcus aureus: origin, evolution and public health threat. Fitzgerald JR. Trends Microbiol 2012; 20: 192. A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. Wilson GJ, Seo KS, Cartwright RA, Connelley T, Chuang-Smith ON, Merriman JA, Guinane CM, Park JY, Bohach GA, Schlievert PM, Morrison WI, Fitzgerald JR. PLOS Pathog 2011; 7: e1002271. Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus. Lowder BV, Guinane CM, Ben Zakour NL, Weinert LA, Conway-Morris A, Cartwright RA, Simpson AJ, Rambaut A, Nübel U, Fitzgerald JR. Proc Natl Acad Sci U S A 2009; 106: 19545. A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. Ganesh VK, Rivera JJ, Smeds E, Ko YP, Bowden MG, Wann ER, Gurusiddappa S, Fitzgerald JR, Höök M. PLoS Pathog 2008; 4: e1000226. Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3): emergence of a virulent subtype with potential risk to public health. Guinane CM, Sturdevant DE, Herron-Olson L, Otto M, Smyth DS, Villaruz AE, Kapur V, Hartigan PJ, Smyth CJ, Fitzgerald JR. J Infect Dis. 2008 Jan 15;197(2):205-13. doi: 10.1086/524689. Complete list of Prof Ross Fitzgerald publications (Google Scholar) This article was published on 2024-09-02
