Publications

Most recent publications from the MacRae lab:

  1. Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.Tang, Q., Tang, K. T., Markby, G., Parys, M., Phadwal, K., MacRae, V. & Corcoran, B., Jul 2025, In: Autophagy. 21, 7, p. 1433-1455 23 p.Research output: Contribution to journal › Article › peer-review
  2. Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder: Mitochondrial dysfunction in renal osteodystrophy. Hsu, S.-N., Stephen, L., Phadwal, K., Dillon, S., Nicholas Carter, R., Morton, N., Luijten, I., Emelianova, K., Amin, A., MacRae, V., Freeman, T., Hsu, Y.-J., Staines, K. A. & Farquharson, C., Jun 2025, In: Kidney International. 107, 6, p. 1017-1036 20 p. Research output: Contribution to journal › Article › peer-review
  3. Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells. Phadwal, K., Haggarty, J., Thekkedath Kurian, D., Aguilar, J., Sun, J., Houston, R. D., Betancor, M., MacRae, V., Whitfield, P. D. & Macqueen, D., Jun 2025, In: Molecular and Cell Biology of Lipids. 1870, 5, p. 1-45 45 p., 159636.Research output: Contribution to journal › Article › peer-review
  4. Nutrient restriction protects against valve interstitial cell calcification by upregulating ubiquitin mediated proteolysis. Phadwal, K., Tang, P. T., Thekkedath Kurian, D., Tan, X., Cawthorn, W. P. & MacRae, V., 2025, In: Frontiers in Cardiovascular Medicine. 12, p. 1-12 12 p. Research output: Contribution to journal › Article › peer-review
  5. The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification. Wang, Y., He, S., Lan, L., Yu, H., Zhao, H., Xie, Y., Zhong, G., Yuan, L., Li, K., Hu, X., Macrae, V. E., Fu, X., Chen, G. & Zhu, D., 10 Dec 2024, (E-pub ahead of print) In: Cardiovascular Research. p. 1-59 59 p. Research output: Contribution to journal › Article › peer-review
  6. Mitochondrial Dysfunction as a Potential Mechanism Mediating Cardiac Comorbidities in Parkinson's Disease. Salis Torres, A., Lee, J.-E., Caporali, A., Semple, R. K., Horrocks, M. H. & MacRae, V. E., Oct 2024, In: International Journal of Molecular Sciences. 25, 20, p. 1-30 30 p., 10973. Research output: Contribution to journal › Review article › peer-review

All MacRae lab research publication outputs can be viewed on the University of Edinburgh Research Profile here: 

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