Dr Stephen uses transgenic fish and cell models to understand the subcellular processes underlying skeletal development. Current projects are focused on understanding the biogenesis of matrix vesicles, their composition, and how they regulate bone development in mineralisation and beyond. Schematic showing the current understanding of specific mineralisation components of matrix vesicles (MV) alongside Correlative Light Electron Microscopical (CLEM) and live superresolution imaging of MV components in mineralising cells and Alizarin red staining of calcium in mineralised zebrafish scales. (Adapted from Clews et al. Journal of Bone and Mineral Research. 2025, produced using Biorender). This article was published on 2025-09-29
