Genetic engineering

Integrated within the Roslin Institute, LARIF offers specialised infrastructure and expertise in genome editing and transgenesis across all major farmed animal species.

Facilities within the LARIF support transformative research in agriculture, medicine and translation science. 

This is done through the production, rearing and detailed study of genetically modified large animals.

Microinjection as viewed through a microscope
Microinjection as viewed through a microscope

Gene-editing

Our embryology suite enables targeted modifications at the zygote stage, through advanced micro-injection technology and precise tools such as CRISPR-Cas9.

The LARIF provides a fully integrated environment, with:

  • specialised surgical theatres
  • imaging
  • containment
  • environmentally controlled animal rooms

This supports the entire process, from implanting engineered embryos through to rearing and breeding of genetically modified populations.

This enables:

  • the identification of casual genetic variations linked to heritable traits
  • the introduction of beneficial alleles
  • the removal of harmful alleles
  • the development of pathogen resistance.

The potential of the LARIF in enhancing animal health has been evidenced in the generation of CD163-edited pigs that are resistant to porcine reproductive and respiratory syndrome.

Welfare

We are committed to ensuring the highest standards of animal welfare and containment. Our biosecure animal housing maintains safe and controlled conditions that protect both the animals and surrounding environment. 

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