Research

We aim to define the core regulatory networks that regulate differentiation across mammals by comparing embryonic cells from multiple species. To support this comparative framework, the Roslin Institute has initiated a programme to derive new embryonic cell lines from rats and a range of farm animals. Building on this effort, our work focuses on isolating and maintaining livestock stem cells—currently including porcine, bovine and sheep lines—and directing them toward defined cell types relevant to key biological traits in agricultural species. By guiding these cells along specific developmental trajectories, we can model processes fundamental to livestock growth, health, and disease, enabling detailed analysis of how cellular states evolve over time. 

Within our research framework, the Burdon lab is organised around four interconnected research themes:

1.     Control of stem cell differentiation – exploring how embryonic stem cells from mouse, bovine, pig, and sheep can be directed toward specific cell fates.
2.     Host–pathogen interactions – investigating how different breeds of big (wild and domestic) vary in their immune responses to viral infections, including African Swine Fever.
3.     Germ cell development and breeding systems – developing in-vitro gamete production systems and studying reproductive biology in cattle and pigs to enhance breeding efficiency and genetic selection.
4.     Comparative biology – leveraging the physiological and anatomical similarities between different animal species to create powerful in-vitro platforms for studying mechanisms of animal biology and disease.
 

Together, this integrated approach strengthens both agricultural innovation and translational biomedical research.