A selection of case studies undertaken at the University of Edinburgh's Large Animal Research and Imaging Facility. One HealthDeveloping an ovine pulmonary adenocarcinoma model Agricultural Battling bovine tuberculosisEngineering pigs that are genetically resistant to the porcine reproductive and respiratory syndrome (PRRS)Pigs with engineered resistance to Classical Swine FeverUnderstanding how salmonella bacteria colonises farm animals and causes diseaseBiomedicalDeveloping a minimally invasive route to the brainHuman ACE2 transgenic pigs as a large animal model for COVID-19Transgenic pigs for cardiovascular disease researchUsing gene therapy to produce meaningful improvements in the lungs of cystic fibrosis affected individuals3RsRefining the animal experience at LARIF This article was published on Friday 21 August 2026