Animal breeding could become more efficient with an approach that combines DNA-editing techniques with new reproductive technologies. Image Genome-editing technologies could improve animal welfare and productivity. Technologies to edit the DNA of animals – known as genome editing – could improve animal welfare and performance while reducing the environmental footprint of livestock production. Genome-editing tools are precise and cost-effective and could technically be applied on the farm, scientists say. Toolkit for breeders Using genome editing is becoming simpler thanks to the emergence of three cutting-edge reproductive technologies, known as surrogate sire technology, zygote transduction with recombinant adeno-associated virus, and zygote electroporation. Livestock breeders could soon apply genome editing on the farm by using these new tools, which mobilise genome editing for the first time. Risks of unintended edits have been significantly reduced in the latest genome-editing technologies. Unintended edits are detected by comprehensive screening methods and, once identified, they can be eliminated using standard breeding strategies. Growing food demand The global requirement for food keeps increasing in line with a growing world population. Advanced technologies could help meet this demand while minimising environmental impact. Genome editing will allow breeders to improve animal welfare, performance and efficiency, paving the way to a more sustainable future. Edited DNA is regarded as safe to eat, as natural genetic edits occur frequently in nature and are thus present in the food we consume. Realising these benefits now lays in the hands of regulators. Gus McFarlaneResearch Fellow, the Roslin Institute This review study by researchers at the Roslin Institute and the University Hospital RWTH Aachen is published in the journal Frontiers in Sustainable Food Systems. ** The Roslin Institute receives strategic investment funding from the Biotechnology and Biological Sciences Research Council and it is part of the University of Edinburgh’s Royal (Dick) School of Veterinary Studies. ** Related links Scientific publication Gene-edited chicken cells resist bird flu virus Gene-edited pigs are resistant to billion dollar virus
