Leaky vaccines can help prevent transmission of Marek’s disease, chicken study finds. HTML Image So-called leaky vaccines reduce the likelihood of chickens developing the painful symptoms of Marek’s disease. Vaccines that typically manage disease symptoms but fail to prevent infection and spread are more effective than was thought in controlling the severity of a viral disease in chickens. So-called leaky vaccines reduce the likelihood of chickens developing the painful symptoms of Marek’s disease, a study showed. This benefit extends to unvaccinated chickens in the same flock as vaccinated birds, researchers found. Their findings offer valuable insight into Marek’s disease virus, which can lead chickens to develop tumours in various parts of the body, eye cancer, and wing and leg paralysis, eventually leading to death. Economic impact Marek’s disease has implications for animal welfare and the food production industry, as it can lead to a reduction in egg laying and meat being deemed unfit for human consumption. The virus spreads through inhalation of a mix of bird feed, bedding material, bird droppings, feathers and dead skin. It is estimated to cost the poultry industry US$1 billion a year. Leaky vaccines are the most commonly used method of controlling Marek’s disease. Until now, little was known about how these vaccines impact on overall populations, especially in unvaccinated chickens. Flock impact Researchers at the Roslin Institute, in collaboration with researchers from the US Department of Agriculture’s Avian Disease and Oncology Laboratory (ADOL), tested the impact of vaccination on Marek’s disease transmission. One group of chickens received a leaky vaccine – this contained a related live virus originating from turkeys, which causes an immune response but no symptoms. A second group received a sham vaccine, which contained no biological material. Both groups of birds were then infected with Marek’s disease virus. Groups of these infected birds were placed with sets of unvaccinated chickens and more than 97 per cent of birds became infected. However, unvaccinated chickens that had contact with vaccinated birds were less likely to develop full-blown Marek’s disease and there were fewer deaths. This was found to be because vaccinated birds transmitted fewer copies of Marek’s disease virus. In our study, we found that leaky vaccines can provide benefit in terms of reducing the presence and severity of symptoms, and mortality, caused by Marek’s disease even for unvaccinated chickens. We need further research to understand how this effect changes as the virus mutates and in other strains of chickens. Dr Richard BaileyLead scientist and Research Fellow at the Roslin Institute The study was published in the journal PLOS Biology. Our findings suggest that even leaky vaccines can play a key role in reducing disease transmission. However, this is only one component in tackling disease in farmed animals, others include improved animal husbandry and breeding for disease resistance. Professor Andrea Doeschl-WilsonPersonal Chair in Animal Disease Genetics and Modelling at the Roslin Institute **The Roslin Institute receives strategic investment funding from the Biotechnology and Biological Sciences Research Council and it is part of the University of Edinburgh’s Royal (Dick) School of Veterinary Studies. ** Related links Scientific publication Test offers fast insight into chicken immunity Gene linked to bone strength in egg-laying hens
HTML Image So-called leaky vaccines reduce the likelihood of chickens developing the painful symptoms of Marek’s disease. Vaccines that typically manage disease symptoms but fail to prevent infection and spread are more effective than was thought in controlling the severity of a viral disease in chickens. So-called leaky vaccines reduce the likelihood of chickens developing the painful symptoms of Marek’s disease, a study showed. This benefit extends to unvaccinated chickens in the same flock as vaccinated birds, researchers found. Their findings offer valuable insight into Marek’s disease virus, which can lead chickens to develop tumours in various parts of the body, eye cancer, and wing and leg paralysis, eventually leading to death. Economic impact Marek’s disease has implications for animal welfare and the food production industry, as it can lead to a reduction in egg laying and meat being deemed unfit for human consumption. The virus spreads through inhalation of a mix of bird feed, bedding material, bird droppings, feathers and dead skin. It is estimated to cost the poultry industry US$1 billion a year. Leaky vaccines are the most commonly used method of controlling Marek’s disease. Until now, little was known about how these vaccines impact on overall populations, especially in unvaccinated chickens. Flock impact Researchers at the Roslin Institute, in collaboration with researchers from the US Department of Agriculture’s Avian Disease and Oncology Laboratory (ADOL), tested the impact of vaccination on Marek’s disease transmission. One group of chickens received a leaky vaccine – this contained a related live virus originating from turkeys, which causes an immune response but no symptoms. A second group received a sham vaccine, which contained no biological material. Both groups of birds were then infected with Marek’s disease virus. Groups of these infected birds were placed with sets of unvaccinated chickens and more than 97 per cent of birds became infected. However, unvaccinated chickens that had contact with vaccinated birds were less likely to develop full-blown Marek’s disease and there were fewer deaths. This was found to be because vaccinated birds transmitted fewer copies of Marek’s disease virus. In our study, we found that leaky vaccines can provide benefit in terms of reducing the presence and severity of symptoms, and mortality, caused by Marek’s disease even for unvaccinated chickens. We need further research to understand how this effect changes as the virus mutates and in other strains of chickens. Dr Richard BaileyLead scientist and Research Fellow at the Roslin Institute The study was published in the journal PLOS Biology. Our findings suggest that even leaky vaccines can play a key role in reducing disease transmission. However, this is only one component in tackling disease in farmed animals, others include improved animal husbandry and breeding for disease resistance. Professor Andrea Doeschl-WilsonPersonal Chair in Animal Disease Genetics and Modelling at the Roslin Institute **The Roslin Institute receives strategic investment funding from the Biotechnology and Biological Sciences Research Council and it is part of the University of Edinburgh’s Royal (Dick) School of Veterinary Studies. ** Related links Scientific publication Test offers fast insight into chicken immunity Gene linked to bone strength in egg-laying hens
